On May 16, 2013, Harriman, Geraldine C.; Masse, Craig E.; Harwood, James; Bhat, Sathesh; Greenwood, Jeremy Robert published a patent.Application of 64987-16-2 The title of the patent was Preparation of thienopyrimidinedione derivatives as ACC inhibitors. And the patent contained the following:
The present invention provides compounds, specifically thienopyrimidine derivatives I [X = O, S, or NR; R1 = H, (un)substituted alkyl; R2 = halo, R, OR, etc.; or R1 and R2 are taken together to form (un)substituted 4-7 membered partially unsaturated carbocyclo-, or heterocyclo-, benzo-, or 5-6 membered heteroaryl- fused ring; R = H, (un)substituted alkyl, Ph, etc.; L1, L2 = a bond, alkylene, cyclobutylenyl, etc.; R3 = H, halo, CN, etc.; R4 = H, (un)substituted 3-8 membered monocyclic saturated or partially unsaturated carbocyclic ring, etc.; with the provisos], useful as inhibitors of Acetyl CoA Carboxylase (ACC), pharmaceutical compositions thereof, and methods of using the same for treating ACC-mediated disorders such as obesity, dyslipidemia, hyperlipidemia, fungal, parasitic or bacterial infections in a subject. The invention further provides a method of inhibiting ACC in a plant comprising contacting the plant with the inhibitor compound I. Over three-hundred compounds I were prepared E.g., a multi-step synthesis of (2S)-II, starting from Et 3-oxobutanoate and Et 2-cyanoacetate, was described. Exemplified compounds I were tested in in vitro ACC1 and ACC2 inhibition assays (data given). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application of 64987-16-2
The Article related to thienopyrimidinedione preparation acetyl coa carboxylase acc inhibitor metabolic disorder, antiobesity fungicide antiparasitic antibacterial thienopyrimidinedione preparation acc inhibitor, dyslipidemia hyperiipidemia treatment thienopyrimidinedione preparation acc inhibitor, thienopyrimidine preparation acetyl coa carboxylase acc inhibitor metabolic disorder and other aspects.Application of 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica