Sagnou, Marina; Tzanopoulou, Stamatia; Raptopoulou, Catherine P.; Psycharis, Vassilis; Braband, Henrik; Alberto, Roger; Pirmettis, Ioannis C.; Papadopoulos, Minas; Pelecanou, Maria published an article in 2012, the title of the article was A Phenylbenzothiazole Conjugate with the Tricarbonyl fac-[M(I)(CO)3]+ (M = Re, 99Tc, 99mTc) Core for Imaging of β-Amyloid Plaques.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole And the article contains the following content:
The 2-(4′-aminophenyl)-6-methylbenzothiazole that is known to display affinity and specificity toward the amyloid plaques of Alzheimer’s disease (AD) has been joined to the tricarbonyl [M(CO)3NNO] chelate (M = Re, 99Tc, and 99mTc) through a five-carbon linker chain to generate the neutral complex (1) (namely, Re-1 for M = Re; 99Tc-1 for M = 99Tc; and 99mTc-1 for M = 99mTc) with the aim of developing a single-photon emission computed tomog. (SPECT) radiodiagnostic agent for AD. Re-1 was characterized by spectroscopic methods and x-ray crystallog., whereas the detailed NMR spectroscopic anal. of 99Tc-1 demonstrated its structural similarity to Re-1. Complexes Re-1 and 99Tc-1 display selective binding affinity for amyloid plaques as evidenced by fluorescence spectroscopy, whereas the biodistribution data of 99mTc-1 characterized by relatively low brain uptake, fast clearance from brain and blood, and in vivo stability are considered encouraging for further elaboration on the structural features of 1 in the direction of increased brain uptake. The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole
The Article related to radiolabeled benzothiazole chelate conjugate spect imaging amyloid alzheimers, crystal structure rhenium benzothiazolyl phenylaminocarbonylbutyl pyridinylmethyl aminoacetate tricarbonyl complex, mol structure rhenium benzothiazolyl phenylaminocarbonylbutyl pyridinylmethyl aminoacetate tricarbonyl complex and other aspects.Safety of 2-(4-Aminophenyl)-6-methylbenzothiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica