On January 1, 2019, Chen, Lingfeng; Chen, Hongjin; Chen, Pengqin; Zhang, Wenxin; Wu, Chao; Sun, Chuchu; Luo, Wu; Zheng, Lulu; Liu, Zhiguo; Liang, Guang published an article.HPLC of Formula: 2010-06-2 The title of the article was Development of 2-amino-4-phenylthiazole analogues to disrupt myeloid differentiation factor 88 and prevent inflammatory responses in acute lung injury. And the article contained the following:
The synthesis of 47 new analogs by modifying different sites on this lead compound and assessed their anti-inflammatory activities in lipopolysaccharide-induced mouse primary peritoneal macrophages (MPMs) was described. The most promising compound I was found to effectively interact with MyD88 protein and prevented formation of the MyD88 homodimeric complex. Furthermore, compound I showed in-vivo anti-inflammatory activity in LPS-caused model of acute lung injury. This work provided new candidates as MyD88 inhibitors to combat inflammation diseases. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).HPLC of Formula: 2010-06-2
The Article related to piperazinyl phenylthiazolylpropanamide preparation myd88 protein homodimerization inhibitor antiinflammatory, 2-amino-4-phenylthiazole, acute lung injury, anti-inflammation, macrophages, myd88 and other aspects.HPLC of Formula: 2010-06-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica