On March 20, 2012, Murray, Anthony; Lau, Jesper; Vedsoe, Per published a patent.Synthetic Route of 859522-19-3 The title of the patent was Urea glucokinase activators. And the patent contained the following:
This application relates to novel urea glucokinase activators and use of the compounds of the invention for preparation of a medicament for the treatment of various diseases, e.g. for the treatment of type 2 diabetes. Further encompassed is a pharmaceutical composition comprising a compound according to the invention and a process for preparing such. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Synthetic Route of 859522-19-3
The Article related to arylcyclopentylmethylureidothiazolylthioalkanoate preparation glucokinase activator, diabetes hyperglycemia obesity dyslipidemia treatment thiazolylthioalkanoate ureido aryl cyclopentylmethyl and other aspects.Synthetic Route of 859522-19-3
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica