On May 16, 2022, Kong, Weixi; Liu, Yunting; Huang, Chen; Zhou, Liya; Gao, Jing; Turner, Nicholas J.; Jiang, Yanjun published an article.Reference of 2-Acetylthiazole The title of the article was Direct Asymmetric Reductive Amination of Alkyl (Hetero)Aryl Ketones by an Engineered Amine Dehydrogenase. And the article contained the following:
The direct asym. reductive amination of heteroaryl ketones has been a long-standing synthetic challenge. Here we report the engineering of an amine dehydrogenase (AmDH) from Jeotgalicoccus aerolatus for the asym. synthesis of chiral α-(hetero)aryl primary amines in excellent conversions (up to 99%) and enantioselectivities (up to 99% ee). The best AmDH variant (Ja-AmDH-M33) exhibited high activity and specificity toward alkyl (hetero)aryl ketones, even for those bearing a bulky alkyl chain. An efficient directed evolution approach based on mol. docking was implemented to enlarge the active pocket with a more hydrophobic entrance, which is responsible for the high activity. The Ja-AmDH-M33 was also used for preparative-scale synthesis of pharmaceutically relevant amines and a key intermediate of chiral pincer ligands, which highlighted its practical application in synthetic chem. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Reference of 2-Acetylthiazole
The Article related to jeotgalicoccus amination alkyl aryl ketone amine dehydrogenase mutation, alkyl (hetero)aryl ketones, amine dehydrogenase, asymmetric reductive amination, chiral amines, directed evolution and other aspects.Reference of 2-Acetylthiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica