On December 31, 2019, Kizimova, I. A.; Igidov, N. M.; Dmitriev, M. V.; Chashchina, S. V.; Makhmudov, R. R.; Siutkina, A. I. published an article.Application In Synthesis of 4-Phenylthiazol-2-amine The title of the article was Synthesis, Structure, and Biological Activity of 4-R-4-Oxo-2-[2-(phenylamino)benzoyl]hydrazinylidene-N-hetarylbutanamides. And the article contained the following:
Decyclization of N’-[5-R-2-oxofuran-3(2H)-ylidene]-2-(phenylamino)benzohydrazides I (R = Ph, t-Bu, 4-chlorophenyl, etc.) under the action of heterocyclic amines R1NH2 (R1 = thiazol-2-yl, 1,3,4-thiadiazol-2-yl, 4-phenylthiazol-2-yl, etc.) leads to the formation of N-hetaryl-4-R-4-oxo-2-[2-(phenylamino)benzoyl]hydrazinylidenebutanamides II and in some cases ring-chain tautomers. Antinociceptive and anti-inflammatory activities of the obtained compounds were studied. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Application In Synthesis of 4-Phenylthiazol-2-amine
The Article related to hetaryl oxo phenylamino benzoyl hydrazinylidene butanamide preparation antinociceptive antiinflammatory, oxofuranylidene phenylamino benzohydrazide heterocyclic amine decyclization and other aspects.Application In Synthesis of 4-Phenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica