Gaddam, Lakshmi Teja; Thata, Sreenivasulu; Adivireddy, Padmaja; Venkatapuram, Padmavathi published an article in 2019, the title of the article was Synthesis of carboxamide and sulfonyl carboxamide linked heterocycles under green conditions.HPLC of Formula: 2010-06-2 And the article contains the following content:
Direct coupling of heteroaldehydes RCHO (R = furan-2-yl, pyridin-4-yl, 2,4-dichloro-1,3-oxazol-5-yl, etc.) with heteroaryl amines R1NH2 (R1 = 4-phenyl-1H-imidazol-2-yl, 4-phenyl-1,3-thiazol-2-yl)/sulfonylamine N-(5-(aminosulfonyl)-4-phenyl-1H-imidazol-2-yl)benzamide is performed under green conditions using PEG-400 in the presence of oxidant CCl3CN/H2O2. The presence of electron withdrawing substituents on heteroaldehydes increased the yield. Further heteroaryl amines favor the reaction when compared with heteroaryl sulfonylamines. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).HPLC of Formula: 2010-06-2
The Article related to carboxamide preparation green chem, heteroaldehyde heteroaryl amine coupling reaction, sulfonyl carboxamide preparation green chem, sulfonylamine heteroaldehyde coupling reaction and other aspects.HPLC of Formula: 2010-06-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica