On January 27, 1998, Iwasaki, Fumiaki; Miharu, Michiko published a patent.SDS of cas: 64987-16-2 The title of the patent was Preparation of 2-aminothiazoleacetic acids as intermediates for cephem antibiotics.. And the patent contained the following:
Title compounds I (R1 = H; X = two H, O, NOR2; R2 = H, alkyl, OH-protecting group; R3 = NH2-protecting group) are prepared by reaction of heterocycles I (R3 = H; R1 = CO2H-protecting group; X, R2, = same as above) with NH2-protecting agents in organic solvents incompatible with H2O, saponification of thiazoles I (R1 = CO2H-protecting group; R3 = NH2-protecting group; R2, X = same as above) (II) with basic aqueous solution, dissolution of II alkali metal salts in basic aqueous solution, neutralizing them with acids, and isolation. I (R3 = H, X = two H, R1 = Et) was treated with (t-BuO)2CO in PhMe in the presence of 4-N,N-dimethylaminopyridine at 50° for 7 h, saponified with NaOH in H2O at 20° for 1 h, and neutralized with HCl in H2O at ≤20° to give 82.5% I (R1 = H, X = two H, R3 = t-BuO2C). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).SDS of cas: 64987-16-2
The Article related to amino protecting agent condensation thiazoleacetate, thiazoleacetate saponification base aqueous solution, aminothiazoleacetic acid preparation cephem antibiotic intermediate and other aspects.SDS of cas: 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica