On December 18, 2008, Gaufreteau, Delphine; Nettekoven, Matthias; Plancher, Jean-Marc; Roche, Olivier; Schmitt, Sebastien; Takahashi, Tadakatsu published a patent.Application In Synthesis of 2-Bromo-N-methylthiazole-4-carboxamide The title of the patent was Preparation of cyclohexyl piperazinyl methanones as modulators of histamine H3 receptors.. And the patent contained the following:
Title compounds [I; R1 = alkyl, cycloalkyl; R2 = (substituted) heteroarylphenyl, heterocyclylphenyl, heteroaryl], were prepared Thus, cis-4-hydroxycyclohexanecarboxylic acid, 1-cyclobutylpiperazine dihydrochloride, TBTU, and diisopropylethylamine were stirred together for 8 h at room temperature in DMF to give 76% amide, which was stirred with 4-(1,2,4-triazol-1-yl)phenol, Ph3P, and di-tert-Bu azodicarboxylate in THF for 72 h to give 11% trans-(4-cyclobutylpiperazin-1-yl)-[4-[4-[1,2,4]triazol-1-ylphenoxy]cyclohexyl]methanone. The latter showed a Ki value of 6.5 nM in an H3 binding assay. The experimental process involved the reaction of 2-Bromo-N-methylthiazole-4-carboxamide(cas: 1092942-42-1).Application In Synthesis of 2-Bromo-N-methylthiazole-4-carboxamide
The Article related to cyclohexyl piperazinyl methanone preparation histamine h3 receptor modulator, obesity diabetes treatment cyclohexylcarbonylpiperazine preparation antihistamine, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application In Synthesis of 2-Bromo-N-methylthiazole-4-carboxamide
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica