On July 7, 2011, Su, Wei-Guo; Jia, Hong; Dai, Guangxiu published a patent.Application of 19989-66-3 The title of the patent was Preparation of triazolopyrazine derivatives and analogs for use as c-MET kinase activity inhibitors. And the patent contained the following:
Title compounds I [X = N or CR6; Y = absent, O, S, or NR7; R1 = (un)substituted fused bicyclic heteroaryl, when X is CR6 and Y is absent; or (un)substituted aryl or heteroaryl, when X is N and Y is o, S, or NR7; or (un)substituted heteroaryl, when X is CR6 and Y is O, S, or NR7; R2 and R3 independently = H, or alkyl; or together with the C atom to which they are attached form a cycloalkyl or heterocyclyl; R4 = halo, (un)substituted alkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl; R6 = H, OH, NH2, halo, etc.; R5 = H, halo, OH NH2, CF3, etc.; R7 = H or alkyl; with provisions], and their pharmaceutically acceptable salts, are prepared and disclosed as c-MET kinase activity inhibitors. Thus, e.g., II was prepared by a multistep procedure (preparation given). Select I were evaluated in c-MET kinase activity inhibition assays (using transcreener FP) (data given). The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Application of 19989-66-3
The Article related to pyrazine triazolo derivative preparation cmet kinase activity inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Application of 19989-66-3
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica