On July 20, 2011, Su, Weiguo; Jia, Hong; Dai, Guangxiu published a patent.Safety of Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of triazolo[b]pyridine and triazolo[b]pyrazine derivatives as antitumor agents. And the patent contained the following:
Title compounds I [X = N or C(R6); Y = O, S, or NR7; R1 = (un)substituted aryl, aromatic heterocyclic group, or fused aromatic hetero-bicyclic group; R2 and R3 = H or alkyl; or R2 and R3 with the carbon which they connect to form 3- to 7-membered cycloalkyl or heterocycloalkyl; R4 = alkyl, cycloalkyl, heterocyclic group, aryl, or aromatic heterocyclic group; R6 = H, OH, NH2, halo, etc.; R7 = H or alkyl], and their pharmaceutically acceptable salts as antitumor agents, which show inhibitor effects on C-Met expression. Thus, e.g., II was prepared by condensation reaction of 3,5-dibromo-2-pyrazinamine with 1H-pyrrolo[2,3-b]pyridine-3-methanamine followed by cyclization and Suzuki reaction with 1-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole. Compounds of the invention were evaluated for their inhibitory activity of c-Met kinase with IC50 values of typically ranging from 0.001 μM to 1 μM. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Safety of Benzo[d]thiazol-6-ylmethanol
The Article related to triazolopyridine triazolopyrazine preparation c met kinase antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Safety of Benzo[d]thiazol-6-ylmethanol
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica