On November 27, 2008, Mitchell, Jeffrey Peter; Lilly, Michael John; Lambert, John Nicholas; Draffan, Alistair George; Bond, Silas; Hufton, Richard; Jahangiri, Saba published a patent.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of substituted arylindazolinone derivative and analogs as viral polymerase inhibitors. And the patent contained the following:
Title compounds I [L = absent or linker; each Y independently = N, NO, or CR4; Z = O, S, or R5; R1 = (un)substituted alkyl, cycloalkyl, aryl, etc.; R2 = (un)substituted cycloalkyl, aryl, or heterocyclyl; R3 = halo, CN, (un)substituted alkyl, etc.; R4 = H, halo, SH, OH, etc.; R5 = H, OH, (un)substituted alkyl, etc.; n = 0 to 4], and their pharmaceutically acceptable salts, are prepared and disclosed as viral polymerase inhibitors. Thus, e.g., II was prepared by amidation of 2-amino-5-bromobenzoic acid with 4-benzyloxyaniline hydrochloride followed by arylation with bromobenzene and cyclization. Select I were evaluated in HCV polymerase inhibition assays (data given). I were disclosed as therapeutic agents for use as viral polymerase inhibitors, in particular inhibitors of viral polymerases within the Flaviviridae family such as hepatitis C virus (HCV). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to indazolinone aryl derivative preparation viral polymerase inhibitor, arylindazolinone analog preparation viral polymerase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica