Chopra, Rakesh; Singh, Lovepreet; Chibale, Kelly; Singh, Kamaljit published an article in 2019, the title of the article was Synthesis, In Silico Molecular Docking, ADME Evaluation and In Vitro Antiplasmodial Activity of Pyrimidine-Based Hybrid Molecules.Category: thiazole And the article contains the following content:
Synthesis of new pyrimidine based mol. hybrids comprising of pyrimidine and aryl/heteroaryl groups linked, conveniently through 1,2,3-triazole. In vitro antiplasdmodial activity of this series of compounds against chloroquine sensitive NF54 strain of the human malaria parasite Plasmodium falciparum, revealed interesting trends and correlation with the physicochem. properties of the hybrids. In silico docking of the most active (IC50 4.40±1.00 μM) (more active than reference artesunate) member 16a in the active binding sites of wild type PfDHFR-TS (P. falciparum Dihydrofolate Reductase-Thymidylate Synthase) and PfDHFR-TS Quadruple mutant showed interactions suggesting their role as PfDHFR inhibitors. Further, all the members of the series showed favorable in silico ADME (Adsorption Distribution, Metabolism, Excretion) profile. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Category: thiazole
The Article related to pyrimidine based hybrid triazoles preparation mol docking antiplasmodial human, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Category: thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica