On May 22, 2014, Lemieux, Rene M.; Popovici-Muller, Janeta; Salituro, Francesco G.; Saunders, Jeffrey O.; Travins, Jeremy; Chen, Yongsheng published a patent.Electric Literature of 64987-16-2 The title of the patent was Preparation of substituted bisthiadiazoles as glutaminase inhibitors. And the patent contained the following:
The invention relates to compounds of formula I as glutaminase inhibitors; their preparation and use in the treatment of cancer. Compounds of formula I wherein X is C3-7 cycloalkylene; each W, Y and Z is independently S, CH, O, N, etc.; A is (CH2)0-2; each R1 and R2 are independently NH2, NR3COR4, CONR3R4, etc.; R3 is H, C1-6 alkyl and aryl; R4 is C1-6 alkyl, aryl, heteroaryl, etc.; each R6 is H, F, OH, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by a general procedure (procedure given). The invention compounds were evaluated for their glutamase inhibitory activity. From the assay, it was determined that example compound II exhibited IC50 value of < 100 nM. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Electric Literature of 64987-16-2
The Article related to substituted bisthiadiazole preparation glutaminase inhibitor treatment cancer, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Electric Literature of 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica