On May 14, 2009, Bouillot, Anne Marie Jeanne; Laroze, Alain published a patent.Formula: C6H8N2O2S The title of the patent was Triazole derivatives as SCD inhibitors and their preparation, pharmaceutical compositions and use in the treatment of SCD-mediated diseases. And the patent contained the following:
The invention relates to substituted triazole compounds of the formula I: and salts thereof, to pharmaceutical compositions containing them and their use in medicine. In particular, the invention relates to compounds for inhibiting SCD activity, such as diseases related to elevated lipid levels, cardiovascular disease, diabetes, obesity, metabolic syndrome, skin disorders such as acne, diseases or conditions related to cancer and the treatment of symptoms linked to the production of the amyloid plaque-forming AB42 peptide such as Alzheimer’s disease and the like. Compounds of formula I wherein X is CONH, NHCO and CH2NH; R1 is (un)substituted C6-10 aryl; R2 is H, C1-6 alkyl and C1-3 alkyl-O-C1-3 alkyl; R3 is (un)substituted C5-9 heteroaryl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by 1-[(3,4-dichlorophenyl)methyl]-5-methyl-1H-1,2,3-triazole-4-carboxylic acid with 2-amino-6-methoxybenzothiazole. All the invention compounds were evaluated for their SCD inhibitory activity. Example compound II and several other example compounds exhibited pIC50 values of greater than 5.5. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Formula: C6H8N2O2S
The Article related to triazole preparation stearoyl coa desaturase inhibitor treatment disease, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Formula: C6H8N2O2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica