On March 9, 2017, Smallheer, Joanne M.; Shaw, Scott A.; Halpern, Oz Scott; Hu, Carol Hui; Kick, Ellen K. published a patent.Application In Synthesis of Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of triazolopyridines as inhibitors of myeloperoxidase. And the patent contained the following:
The invention provides compounds of formula I and compositions comprising any of such compounds These compounds are myeloperoxidase (MPO) inhibitors and/or eosinophil peroxidase (EPX) inhibitors, which may be used as medicaments. Compounds of formula I wherein A is (un)substituted 5-membered heteroaryl; and stereoisomers, tautomers, pharmaceutically acceptable salts and solvates thereof, are claimed. Example compound II•TFA was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their MPO inhibitory activity. From the assay, it was determined that compound II exhibited IC50 values in the range of 1 nM to 100 nM. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Application In Synthesis of Benzo[d]thiazol-6-ylmethanol
The Article related to triazolopyridine preparation myeloperoxidase inhibitor, Heterocyclic Compounds (More Than One Hetero Atom): Other 5-Membered Rings, Two Or More Hetero Atoms and other aspects.Application In Synthesis of Benzo[d]thiazol-6-ylmethanol
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica