On October 1, 2009, Muthuppalniappan, Meyyappan; Kumar, Sukeerthi; Thomas, Abraham; Khairatkar-Joshi, Neelima; Mukhopadhyay, Indranil published a patent.Synthetic Route of 31699-14-6 The title of the patent was Preparation of phthalimide derivatives as TRPA1 modulators. And the patent contained the following:
The present invention provides TRPA (Transient Receptor Potential subfamily A) modulators. In particular, compounds I [ring A = (hetero)aryl, heterocyclyl, cycloalkyl; R1 = H, OH, (un)substituted alkyl, etc.; R2 = H, CN, NO2, etc.; R3, R4 = H, OH, halo, etc.; or R3 and R4 may be joined together to form (un)substituted 3-7 membered (un)saturated cyclic ring which may optionally include at least one heteroatom such as O, S, (un)substituted NH, C(O), S(O)0-2; R5 = H, OH, (un)substituted alkyl, etc.] are useful for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1) modulators. Forty-four compounds I were prepared Thus, coupling the acid II (multi-step synthesis was given) with 4-isopropylaniline afforded the title compound III. Exemplified compounds I were screened for TRPA1 antagonist activity using the 45Calcium uptake assay (data given). Also provided are processes for preparing compounds I, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Synthetic Route of 31699-14-6
The Article related to phthalimide amide preparation transient receptor potential a trpa1 modulator, isoindolylacetamide preparation transient receptor potential a trpa1 modulator, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Synthetic Route of 31699-14-6
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica