On September 15, 1977, Kamiya, Takashi; Tanaka, Kunihiko; Nakai, Yoshiharu; Sakane, Kazuo published a patent.Category: thiazole The title of the patent was 3,7-Disubstituted-3-cephem-4-carboxylic acid derivatives. And the patent contained the following:
Cephalosporin derivatives (∼100 compounds) including I (X = CO, CHOH; X1 = S, NMe, X2 = CH; X1 = S, O, X2 = CHMe; X1 = NMe, X2 = N) were prepared Thus, the aminothiazolylacetate II (R = H, R1 = Et, X = CH2) was formylated, I (R = CHO, R1 = Et, X = CH2) oxidized with SeO2, I (R = CHO, R1 = Et, X = CO) hydrolyzed, and I (R = CHO, R1 = H, X = CO) used to acylate 3-(1-methyl-5-tetrazolylthiomethyl)-7-amino-3-cephem-4-carboxylic acid, followed by cleavage of the formyl group with POCl3 to give I (X = CO, X1 = NMe, X2 = N). This compound had a min. inhibitory concentration against Escherichia coli 0.05 μg/mL. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Category: thiazole
The Article related to cephalosporin, aminothiazolylacetamidocephem, thiazolylacetamidocephem, Heterocyclic Compounds (More Than One Hetero Atom): Thiazines (Including Cephalosporins) and other aspects.Category: thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica