On October 31, 2019, Igidov, N. M.; Rubtsov, A. E. published an article.Quality Control of 4-Phenylthiazol-2-amine The title of the article was Ring Opening of 4-Arylamino-2-tert-butyl-5-oxo-2,5-dihydrofuran-2-yl Acetates with Aromatic and Heterocyclic Amines. And the article contained the following:
Reactions of 4-arylamino-2-tert-butyl-5-oxo-2,5-dihydrofuran-2-yl acetates I [Ar = 2,4-dichlorophenyl, 2,4-dimethylphenyl, 4-(ethoxy(oxo)methyl)phenyl, etc.] with an equimolar amount of aromatic/heterocyclic amines RNH2 (R =phenyl, 2-bromophenyl, pyridin-2-yl, etc.) in toluene involves initial attack of the amine on the C2 atom of the furan ring, followed by opening of the furan ring and elimination of acetic acid to give N-aryl(hetaryl)-2-arylamino-5,5-dimethyl-4-oxohex-2-enamides RNHC(O)C(=CHC(O)C(CH3)3)NHAr. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Quality Control of 4-Phenylthiazol-2-amine
The Article related to aryl arylamino dimethyl oxo hexenamide preparation diastereoselective, arylamine arylamino tertbutyl oxo dihydrofuranyl acetate ring opening reaction, Aliphatic Compounds: Amides, Amidines, Imidic Esters, Hydrazides, and Hydrazonic Esters and other aspects.Quality Control of 4-Phenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica