On January 29, 2004, Vaccaro, Wayne; Yang, Bingwei Vera; Kim, Soong-hoon; Huynh, Tram; Tortolani, David R.; Leavitt, Kenneth J.; Li, Wenying; Doweyko, Arthur M.; Chen, Xiao-tao; Doweyko, Lidia published a patent.Recommanded Product: 31699-14-6 The title of the patent was Preparation of dibenzofused bicyclo[2.2.2]octane-derived amides as modulators of the glucocorticoid receptor. And the patent contained the following:
Title compounds I [R-R4 = H, alk(en/yn)yl, alkoxy, aryl, etc.; Z = carboxamido, alkylamino, etc.] are prepared For instance, 2-amino-4,5-dimethylthiazole is coupled to the acid derived from the cycloaddition of methacrylic acid and anthracene (CH3CN, EDCI, Et3N, HOAt, 18 h) to give II. I are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Recommanded Product: 31699-14-6
The Article related to modulator glucocorticoid receptor bicyclo amide preparation, Alicyclic Compounds: Bicyclic Compounds, Including Azulenes, Heptalenes, and Pentalenes and other aspects.Recommanded Product: 31699-14-6
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica