On November 13, 2008, Yamashita, Haruhisa; Odai, Osamu; Harada, Hiroshi; Iwata, Mitsutaka published a patent.Formula: C6H8N2O2S The title of the patent was Preparation of fused heterocyclic derivatives as glucokinase (GK) activators. And the patent contained the following:
Title compounds I [A = -N(R3)(CH2)m-, -N(R3)CO(CH2)m- or -N(R3)SO2(CH2)m-; m = 0-2; X1, X2 = -CO-, -CS- or -C(R4)(R5)-; X3 = -C(R4)(R5)-; R1 = H, (un)substituted alkyl, (un)substituted cycloalkyl, etc.; R2 = H, (un)substituted alkyl, (un)substituted alkenyl, etc.; R3 = H, (un)substituted alkyl or (un)substituted cycloalkyl; R4, R5 = H, halo or (un)substituted alkyl; n = 1 or 2] or their pharmaceutically acceptable salts were prepared For example, Pd2(dba)3 catalyzed reaction of compound II [R = Cl], e.g., prepared from Et 4-oxopiperidine-3-carboxylate hydrochloride in 3 steps, with 2-aminothiazole afforded compound II [R = thiazol-2-ylamino], which showed 328% GK activation. Compounds I are claimed useful for the treatment of diabetes. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Formula: C6H8N2O2S
The Article related to fused heterocycle preparation glucokinase gk activator, diabetes treatment fused heterocycle preparation gk activation, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Formula: C6H8N2O2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica