On December 31, 2009, Muthuppalniappan, Meyyappan; Thomas, Abraham; Kumar, Sukeerthi; Margal, Sanjay; Khairatkar-Joshi, Neelima; Mukhopadhyay, Indranil; Gullapalli, Srinivas published a patent.Reference of 2-Amino-4-(4-iodophenyl)thiazole The title of the patent was Preparation of quinazolinedione derivatives as TRPA1 modulators. And the patent contained the following:
The title compounds I [ring A = (hetero)aryl, heterocyclyl, cycloalkyl; R1, R2 = H, OH, alkyl, etc.; R3, R4 = H, OH, halo, etc.; or R3 and R4 may be joined together to form (un)substituted 3-7 membered (un)saturated cyclic ring which may optionally include one or more heteroatom or group selected from O, S, C(O), S(O)0-2, (un)substituted NH; R5 = H, OH, alkyl, etc.; R6 = H, CN, NO2, etc.; n = 0-5], useful as TRPA (Transient Receptor Potential subfamily A) modulators for treating or preventing diseases, conditions and/or disorders modulated by TRPA1 (Transient Receptor Potential subfamily A, member 1), were prepared E.g., a multi-step synthesis of II, starting from 2-amino-6-nitrobenzoic acid and urea, was given. Exemplified compounds I were screened for TRPA1 activity. For example, II showed 90.73% inhibition at 10.0 μM using the 45Calcium Uptake Assay. Also provided are processes for preparing compounds I, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPA1. The experimental process involved the reaction of 2-Amino-4-(4-iodophenyl)thiazole(cas: 31699-14-6).Reference of 2-Amino-4-(4-iodophenyl)thiazole
The Article related to quinazolinedione preparation transient receptor potential channel trpa1 modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Reference of 2-Amino-4-(4-iodophenyl)thiazole
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica