On June 8, 2006, Jeppesen, Lone; Kristiansen, Marit published a patent.Formula: C7H10N2O2S2 The title of the patent was Preparation of N-heteroaromatic propionamides as glucokinase activators for treating diabetes and other diseases. And the patent contained the following:
The present invention describes 2,3-di-substituted N-heteroaromatic propionamides of Formula I ( wherein the * indicates an asym. atom; R1,R2 = H, halo, NH2, NHOH, C1-6 alkyl, perfluoro-C1-6 alkyl, etc.; R3 = C3-7 cycloalkyl and C2-4 alkyl; ring A = a monosubstituted or a disubstituted 5-6 membered heteroaromatic ring consisting of, in addition to the C=N shown, carbon atoms and 0-2 heteroatoms selected from S(O)p, 0, and N; p= 0-2) pharmaceutical compositions comprising the same; and, methods of using the same. The propionamides are glucokinase activators for the treatment II diabetes and other disorders(no data given). The preparation of I is exemplified. For example, II was prepared in 2 steps by reacting intermediate 2-amino-5-(4-methylpiperazin-1-yl)thiazole (preparation given) with 3-cyclopentyl-2-(4-methanesulfonylphenyl)propionic acid. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Formula: C7H10N2O2S2
The Article related to heteroaromatic propionamide preparation glucokinase activator diabetes treatment, metabolic disorder treatment heteroaromatic propionamide glucokinase activator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Formula: C7H10N2O2S2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica