Poola, Sreelakshmi; Gundluru, Mohan; Nadiveedhi, Maheshwara Reddy; Saddala, Madhu Sudhana; P. T. S. R. K., Prasada Rao; Cirandur, Suresh Reddy published an article in 2020, the title of the article was Nano silver particles catalyzed synthesis, molecular docking and bioactivity of α-thiazolyl aminomethylene bisphosphonates.Recommanded Product: 4-Phenylthiazol-2-amine And the article contains the following content:
A new series of α-thiazolyl aminomethylene bisphosphonates I (R1 = H, OCH3, F, Br; R2 = OMe, OEt, OBu, OPh)were synthesized by a three component reaction of 4-aryl substituted thiazol-2-amine with different dialkyl/aryl phosphites and tri-Et orthoformate in the presence of Ag NPs (nano particles) as a catalyst under solvent free conditions. The target compounds were screened for their in vitro antioxidant, antibacterial and antifungal activity. Mol. docking studies were also performed. The results revealed that among the synthesized compounds I (R1 = OCH3, F, Br; R2 = Me) showed remarkably higher antioxidant activity by DPPH and H2O2 than the standard ascorbic acid. Compounds I (R1 = H, OCH3, F; R2 = Me) showed good antibacterial activity and also showed rather higher antifungal activity than the standard flucanozole. Computational docking methods have been used to predict how several aminomethylene bisphosphonate derivatives compete against the inhibitor BPH-1330 at the crystal enzyme structure of the 4H3A protein active site and how substituents influence their binding ability. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).Recommanded Product: 4-Phenylthiazol-2-amine
The Article related to thiazolyl aminomethylene bisphosphonate preparation mol docking antioxidant antibacterial antifungal, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Recommanded Product: 4-Phenylthiazol-2-amine
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica