On February 26, 1986, Onoue, Hiroshi; Takahashi, Hiromi published a patent.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Thiazolylpentenedioic acids. And the patent contained the following:
Esters I (R1 = NH2, protected amino; R2 = standard alc. residue; R3 = H, cyano, esterified CO2H; R4 = H, cyano, esterified CO2H) were prepared Thiazoleacetate ester II was treated with MeOCH:C(CO2Me)2; the product underwent elimination reaction to yield I (R1 = NHCO2CH2Ph, R2 = Me, R3 = R4 = CO2H), and the latter was subjected to hydrolysis-decarboxylation to give I (R1 = NHCO2CH2Ph, R2 = R3 = H, R4 = CO2H). The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to thiazolylpentenedioic acid, glutaconic acid thiazolyl, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Quality Control of Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica