On January 9, 2020, Franch, Luigi; Ghosh, Shomir; Glick, Gary; Katz, Jason; Opipari, Anthony William, Jr.; Roush, William R.; Seidel, Hans Martin; Shen, Dong-Ming; Venkatraman, Shankar; Winkler, David Guenther published a patent.Related Products of 64987-16-2 The title of the patent was Heteroaryl compounds as NLRP modulators and their preparation. And the patent contained the following:
The invention relates to heteroaryl compounds of formula I, or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable salt thereof, and are useful to treat connected to the modulation of NLRP3. Compounds of formula I wherein n is 0 and 1; o is 0, 1, 2 and 3; q is 1 and 2; A and E are independently 5- to 10-membered heteroaryl and C6-10 aryl; R1a is (un)substituted C1-6 alkyl and SONH2 and derivatives; R1b is substituted C1-6 alkyl, SO2NH2 and derivatives, OH and derivatives, etc.; R2 is C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, etc.; R6 and R7 are independently C1-6 alkyl, C1-6 alkoxy, halo, CN, NO2, etc.; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by amidation of 2,2,2-trichloroethyl N-[2-azatricyclo[7.3.0.0[3,7]]dodeca-1,3(7),8-trien-8-yl]carbamate with 3-(hydroxymethyl)-N1-methylbenzene-1,4-disulfonamide. The invention compounds were evaluated for their NLRP3 modulatory activity. From the assay, it was determined that compound II exhibited IC50 value in the range of ≥ 0.2μM to < 1μM. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Related Products of 64987-16-2
The Article related to heteroaryl preparation nlrp3 modulator, Heterocyclic Compounds (More Than One Hetero Atom): Thiazoles, Isothiazoles and other aspects.Related Products of 64987-16-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica