On August 24, 1999, Hirota, Yoshihiro; Matsunaga, Tomonori published a patent.Name: Methyl 2-(2-aminothiazol-4-yl)acetate The title of the patent was Preparation of chloroacetylamino thiazoleacetic acid ester derivatives. And the patent contained the following:
The title cephalosporin intermediates of formula I [X = alkyl, aralkyl; Y = H2, O, alkoxyimino, carbalkoxy-alkoxyimino] are prepared Thus, chloroacetyl chloride was added slowly to Et 2-(2-aminothiazol-4-yl)-2(Z)-methoxyiminoacetate and propylene oxide acid capture agent in THF to give II in 84% yield. The experimental process involved the reaction of Methyl 2-(2-aminothiazol-4-yl)acetate(cas: 64987-16-2).Name: Methyl 2-(2-aminothiazol-4-yl)acetate
The Article related to thiazoleacetic acid ester chloroacetylamino preparation cephalosporin intermediate, Biomolecules and Their Synthetic Analogs: Beta-Lactam Fungal Metabolites and other aspects.Name: Methyl 2-(2-aminothiazol-4-yl)acetate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica