On October 15, 2003, Puetz, Claudia; Sundermann, Bernd; Sundermann, Corinna; Ijzermann, Adriaan Pieter; Tromp, Reynier; Von Frijtag, Drabbe Kuenzel Jacobien published a patent.Electric Literature of 19989-66-3 The title of the patent was Preparation of analogs of nitrobenzylthioinosine for the treatment of pain, epilepsy, and other CNS-related disorders. And the patent contained the following:
This invention relates to new nucleoside analogs I, wherein or derivatives of nitrobenzylthioinosine, use of these new analogs of nitrobenzylthioinosine for the treatment of pain and various other diseases as well as pharmaceuticals comprising at least on new analog of nitrobenzylthioinosine. The derivatives of nitrobenzylthioinosine according to the invention are surprisingly effective in the treatment of pain and in other indications. Therefore a further embodiment of the invention comprises the use of a derivatives of nitrobenzylthioinosine according to the invention for the treatment of pain, especially acute, chronic and/or neuropathic pain. Treatment using derivatives of nitrobenzylthioinosine according to the invention especially for the treatment of pain, especially acute, chronic and/or neuropathic pain; the treatment of epilepsy and other CNS-related disorders as well as for neuro-protection or cardio-protection. A further embodiment of the invention comprises the use of a derivatives of nitrobenzylthioinosine according to the invention for the treatment of epilepsy and other CNS-related disorders as well as for neuroprotection or cardio-protection. Thus, 2-[6-(benzo[c]iso-thiazol-5-ylmethylsulfanyl)-purin-9-yl]-5-hydroxymethyl-tetrahydro-furan-3,4-diol was prepared and tested for the treatment of pain, epilepsy, transport protein on human erythrocyte membranes (Ki > 1.5 nM), and other CNS-related disorders. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Electric Literature of 19989-66-3
The Article related to human nitrobenzylthioinosine nucleoside preparation treatment pain epilepsy cns, Carbohydrates: Nucleosides and Nucleotides, Cobalamins, Riboflavin and other aspects.Electric Literature of 19989-66-3
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica