Simic, Dejan; Zaric, Milan; Nikolic, Ivana; Zivkovic-Zaric, Radica; Canovic, Petar; Kocovic, Aleksandar; Radojevic, Ivana; Rakovic, Ivana; Jovicic Milic, Sandra; Petrovic, Djordje; Stojkovic, Danijela; Vukovic, Nenad; Kacaniova, Miroslava; Vukic, Milena; Jevtic, Verica published an article in 2022, the title of the article was Newly synthesized palladium(II) complexes with aminothiazole derivatives: in vitro study of antimicrobial activity and antitumor activity on the human prostate cancer cell line.SDS of cas: 2010-06-2 And the article contains the following content:
Five new complexes of the palladium(II) ion (C1-C5) having the general formula [(PdL2)]Cl2 with some 2-aminothiazoles (L1-L5), where L1 = 2-amino-4-(3,4-difluorophenyl)thiazole, L2 = 2-amino-5-methyl-4-phenylthiazole, L3 = 2-amino-4-phenylthiazole, L4 = 2-amino-4-(4-chlorophenyl)thiazole, and L5 = 2-amino-4-(2,4-difluorophenyl)thiazole, were synthesized and characterized by elemental microanal. and IR, 1H NMR and 13C NMR spectroscopy. The in vitro antimicrobial activity of the five ligands and the corresponding Pd(II) complexes was studied. Testing was performed by the microdilution method and the min. inhibitory concentration (MIC) and min. microbicidal concentration (MMC) were determined Testing is conducted against 11 microorganisms (nine strains of pathogenic bacteria and two yeast species). The tested ligands and palladium(II) complexes show selective, high and moderate activity. There is a difference in antimicrobial activity between the ligands and the corresponding palladium(II) complexes. The complexes have significant anti-staphylococcal activity and activity on Pseudomonas aeruginosa which is better than the pos. control. The interactions of newly synthesized palladium(II) complexes with calf thymus DNA (CT-DNA) were studied using UV-visible absorption and fluorescence spectroscopy. Anal. of UV-absorption and fluorescence spectra indicates the formation of a complex between the palladium(II) complexes and DNA. The high values of intrinsic binding constants, Kb, of the order 104 M-1 and Stern-Volmer quenching constants, KSV, of the order 105 M-1 indicated very good binding of all complexes to CT-DNA. Also, the new Pd(II) complexes show high cytotoxic activity towards the human prostate cancer cell line and insignificant activity towards non-cancerous human fibroblasts. Future research could addnl. explore the biol. activity of Pd(II) complexes presented in this paper and study the possibility of their implementation in clin. practice. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2
The Article related to palladium aminothiazole derivative complex preparation antimicrobial antitumor activity, dna interaction palladium aminothiazole derivative complex, Inorganic Chemicals and Reactions: Coordination Compounds and other aspects.SDS of cas: 2010-06-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica