Hu, Yuan-Yuan; Wang, Juan; Li, Tie-Jun; Yadav Bheemanaboina, Rammohan R.; Ansari, Mohammad Fawad; Cheng, Yu; Zhou, Cheng-He published an article in 2020, the title of the article was An unexpected discovery toward novel membrane active sulfonyl thiazoles as potential MRSA DNA intercalators.Formula: C5H5NOS And the article contains the following content:
With the increasing emergence of drug-resistant bacteria, the need for new antimicrobial agents has become extremely urgent. This work was to develop sulfonyl thiazoles as potential antibacterial agents. Novel hybrids of sulfonyl thiazoles were developed from com. acetanilide and acetylthiazole. Hybrids 6e and 6f displayed excellent inhibitory efficacy against clin. methicillin-resistant Staphylococcus aureus (MRSA) (min. inhibitory concentration = 1μg/mL) without obvious toxicity toward normal mammalian cells (RAW 264.7). The combination uses were found to improve the antimicrobial ability. Further preliminary antibacterial mechanism experiments showed that the active mol. 6f could effectively interfere with MRSA membrane and insert into MRSA DNA. Compounds 6e and 6f could serve as potential DNA-targeting templates toward the development of promising antimicrobial agents. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS
The Article related to staphylococcus aureus methicillin sulfonyl thiazole dna intercalator, dna, mrsa, antibacterial, antifungal, sulfonyl, thiazole, Pharmacology: Drug Interactions and General Pharmacology and other aspects.Formula: C5H5NOS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica