On September 22, 2005, Lynch, John K.; Collins, Christine A.; Freeman, Jennifer C.; Gao, Ju; Iyengar, Rajesh R.; Judd, Andrew S.; Kym, Philip R.; Mulhern, Mathew M.; Sham, Hing L.; Souers, Andrew J.; Zhao, Gang; Wodka, Dariusz published a patent.Safety of Benzo[d]thiazol-6-ylmethanol The title of the patent was Preparation of piperidinyl chromenecarboxamides as antagonists of melanin concentrating hormone effects on the melanin concentrating hormone receptor. And the patent contained the following:
The present invention is directed to compounds of formula (I, variables defined below), which antagonize the effects of melanin-concentrating hormone (MCH) through the melanin concentrating hormone receptor which is useful for the prevention or treatment of eating disorders, weight gain, obesity, abnormalities in reproduction and sexual behavior, thyroid hormone secretion, diuresis and water/electrolyte homeostasis, sensory processing, memory, sleeping, arousal, anxiety, depression, seizures, neurodegeneration and psychiatric disorders. The variables for I are: L = a bond or alkylene, alkenylene, alkynylene, CH2O, SO2NH, C(O)NH, NHCO, NHSO2, CO, SO and SO2; X = O and N(R13); Z = CH2, C(N-Rc), CO and CS; m = 1 or 2; n = 0-2; R1, R2 and R3 = H, alkenyl, alkoxy, alkyl, alkylcarbonyl, alkylcarbonyl-NH-, alkyl-NH-carbonyl, alkylsulfonyl-NH-, alkyl-NH-sulfonyl, alkylsulfonyl, alkylthio, alkynyl, cyano, halogen, haloalkyl, haloalkoxy, haloalkylthio, nitro, RaRbN, RaRbNC(O)- or R1 and R2 together with intervening atoms form a heteroaryl or heterocycle; R4 = H, alkyl, alkylcarbonyl-NH-, alkylsulfonyl-NH-, aryl and halogen; R5 = H and alkyl; R6 = H, alkyl, aryl, cycloalkyl, heteroaryl and heterocycle; R7 = aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocycle and heterocyclealkyl, or R6 and R7 together with attached atoms form a cycloalkyl or heterocycle; R8 = H, alkyl and alkoxy; R9 = H and alkyl; R10 and R11= H, alkyl, alkoxylalkyl, or R10 and R11 together with intervening atoms form a 5, 6, or 7-membered ring; R12 = H and alkyl; R13 = H, alkyl, aryl, cycloalkyl, heteroaryl and heterocycle; Ra and Rb = H, alkoxycarbonyl, alkyl, alkylcarbonyl, alkyl-NH-carbonyl, alkylsulfonyl, aryl and arylalkyl or Ra and Rb together with the attached N form a heteroaryl or heterocycle; and Rc = H and alkyl; provided that at least one of R1, R2 or R3 are not H. Pharmaceutical formulations containing I are also claimed. The experimental process involved the reaction of Benzo[d]thiazol-6-ylmethanol(cas: 19989-66-3).Safety of Benzo[d]thiazol-6-ylmethanol
The Article related to piperidinyl chromene carboxamide preparation antagonist melanin concentration hormone antiobesity, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of Benzo[d]thiazol-6-ylmethanol
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica