Thomson, Connor J.; Barber, David M.; Dixon, Darren J. published an article in 2020, the title of the article was Catalytic Enantioselective Direct Aldol Addition of Aryl Ketones to α-Fluorinated Ketones.Electric Literature of 24295-03-2 And the article contains the following content:
The catalytic enantioselective synthesis of α-fluorinated chiral tertiary alcs. from (hetero)aryl Me ketones is described. The use of a bifunctional iminophosphorane (BIMP) superbase was found to facilitate direct aldol addition by providing the strong Bronsted basicity required for rapid aryl enolate formation. The new synthetic protocol is easy to perform and tolerates a broad range of functionalities and heterocycles with high enantioselectivity (up to >99:1 e.r.). Multi-gram scalability was demonstrated along with catalyst recovery and recycling. 1H NMR studies identified a 1400-fold rate enhancement under BIMP catalysis, compared to the prior state-of-the-art catalytic system. The utility of the aldol products was highlighted with the synthesis of various enantioenriched building blocks and heterocycles, including 1,3-aminoalc., 1,3-diol, oxetane, and isoxazoline derivatives The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Electric Literature of 24295-03-2
The Article related to enantioselective catalyst aldol aryl ketone alpha fluorinated, aldol, aryl enolates, enantioselective catalysis, organocatalysis, superbase, General Organic Chemistry: Synthetic Methods and other aspects.Electric Literature of 24295-03-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica