On January 22, 2011, Zanda, Matteo; Sani, Monica; Lazzari, Paolo published a patent.Recommanded Product: Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate The title of the patent was Pharmaceutical compositions comprising tubulysin compounds. And the patent contained the following:
The present invention relates to synthetic tubulysin compounds having a high cytotoxicity, with antimitotic and/or antiangiogenic properties, the corresponding solvates and pharmaceutically acceptable salts thereof, their use for the treatment of tumors and/or diseases associated to angiogenesis, and a process for their preparation with high yield. Pharmaceutical compositions comprising tubulysin compounds or their conjugates with polymers or biomols., e.g., proteins, hormones, aptamers, polysaccharides, antibodies and fragments thereof, peptides, vitamins, etc., are disclosed. Thus, (2S,4R)-4-[2-[(1R,3R)-1-acetoxy-3-[(2S,3R)-N-benzyl-3-methyl-2-(1-methylpiperidine-2-carboxamido)pentanamido]-4-methylpentyl]thiazole-4-carboxamido]-2-methyl-5-phenylpentanoic acids was prepared and formulated into nanoparticles of polylactate-polyglycolate copolymer. The high cytotoxicity of the compound against 3 tumor cell lines (HL60, HT29 and A2780) was demonstrated. The experimental process involved the reaction of Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate(cas: 944559-46-0).Recommanded Product: Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate
The Article related to tubulysin compound preparation antitumor antimitotic angiogenesis inhibitor pharmaceutical, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: Ethyl 2-(4-methylpent-2-enoyl)thiazole-4-carboxylate
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica