Stevanovic, Nevena; Jevtovic, Mima; Mitic, Dragana; Matic, Ivana Z.; Crnogorac, Marija Dordjic; Vujcic, Miroslava; Sladic, Dusan; Cobeljic, Bozidar; Andjelkovic, Katarina published an article in 2022, the title of the article was Evaluation of antitumor potential of Cu(II) complex with hydrazone of 2-acetylthiazole and Girard′s T reagent.Formula: C5H5NOS And the article contains the following content:
In this paper, the previously synthesized Cu(II) complex ([CuL1(N3) (CH3OH)]BF4) with N,N,N-trimethyl-2-oxo-2-(2-(1-(thiazol-2-yl)ethylidene)hydrazinyl)ethan-1-aminium chloride, has been characterized and its biol. activity has been studied in detail. The Cu(II) complex consists of ligand coordinated in a deprotonated, formally neutral zwitter-ionic form, via NNO atoms, one azido ligand and one methanol mol. The Cu(II) complex was selected due to results of the cytotoxic activity, the brine shrimp test and DPPH radical scavenging activity, which were previously performed. The effects of Cu(II) complex on cell cycle phase distribution of cervical adenocarcinoma HeLa cells were investigated in order to examine the mechanisms of its anticancer activity. The measurement of intracellular ROS levels in HeLa and HaCaT cell lines were evaluated in order to explore their possible generation and the role in cytotoxic activity. The possible anti-invasive and anti-angiogenic properties of Cu(II) complex were evaluated. DNA binding experiments, including fluorescence displacement study and DNA cleavage experiments, were performed in order to obtain information on the type of DNA-metal complex interactions. The experimental process involved the reaction of 2-Acetylthiazole(cas: 24295-03-2).Formula: C5H5NOS
The Article related to copper complex antitumor agent acetylthiazole girard t reagent adenocarcinoma, Placeholder for records without volume info and other aspects.Formula: C5H5NOS
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica