On January 18, 2007, Murray, Anthony; Lau, Jesper; Vedsoe, Per; Jeppesen, Lone; Kristiansen, Marit published a patent.Related Products of 859522-19-3 The title of the patent was Preparation of dicycloalkylcarbamoyl ureas as glucokinase activators. And the patent contained the following:
Title compounds represented by the formula I [wherein R1 = (cycloalkyl)alkyl, cycloalkyl, heterocyclyl, etc.; R2 = cycloalkyl, cycloalkenyl, heterocyclyl, etc.; R3 = H, alkyl, alkenyl, etc.; R4 = H, (cyclo)alkyl, arylalkyl, etc.; and pharmaceutically acceptable salts thereof] were prepared as glucokinase activators. For example, reaction of dicyclohexyl carbamoyl chloride with methylurea in THF gave II. The glucose sensitivity of I are measured at a compound concentration of 10 μM and at glucose concentrations of 5 and 15 mM. I and their pharmaceutical compositions are useful as activators of glucokinase for the management, treatment, control, or adjunct treatment of diseases, where increasing glucokinase activity is beneficial. The experimental process involved the reaction of Ethyl 2-((2-aminothiazol-5-yl)thio)acetate(cas: 859522-19-3).Related Products of 859522-19-3
The Article related to dicycloalkylcarbamoyl urea preparation glucokinase activator, Alicyclic Compounds: Cyclohexanes and other aspects.Related Products of 859522-19-3
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica