Payaz, Deniz Uzeroglu; Kucukbay, F. Zehra; Kucukbay, Hasan; Angeli, Andrea; Supuran, Claudiu T. published an article in 2019, the title of the article was Synthesis carbonic anhydrase enzyme inhibition and antioxidant activity of novel benzothiazole derivatives incorporating glycine, methionine, alanine, and phenylalanine moieties.Formula: C14H12N2S And the article contains the following content:
Thirteen novel benzothiazole derivatives incorporating glycine, methionine, alanine, and phenylalanine were synthesized by facile acylation reactions through benzotriazole or DCC mediated reactions and their structures were identified by 1H-NMR, 13C-NMR, and FT-IR spectroscopic techniques and elemental anal. The carbonic anhydrase (CA, EC 4.2.1.1) inhibitory activity of the new compounds was assessed against four human (h) isoforms, hCA I, hCA II, hCA V, and hCA XIII. Some of the synthesized compounds showed good in vitro carbonic anhydrase inhibitory properties, with inhibition constants in the micromolar level. The new amino acid benzothiazole conjugates found to be more effective against hCA V and hCA II inhibition. In vitro antioxidant activities of the novel compounds were determined by DPPH method. Most of the synthesized compounds showed moderate to low antioxidant activities compared to the control antioxidant compounds (BHA and α-tocopherol). The experimental process involved the reaction of 2-(4-Aminophenyl)-6-methylbenzothiazole(cas: 92-36-4).Formula: C14H12N2S
The Article related to benzothiazole amino acid synthesis antioxidant carbonic anhydrase, benzothiazole, amino acids, carbonic anhydrase, antioxidant, benzotriazole methodology, Pharmacology: Structure-Activity and other aspects.Formula: C14H12N2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica