On May 25, 2019, Jalal, Mahir A.; TAlmalki, Ziyad; Radhi, Wisam A. published an article.SDS of cas: 2010-06-2 The title of the article was Quantitative structure-activity relationship studies of amino acids conjugated 2-amnio-arylthiazole as antifungal. And the article contained the following:
Thiazole derivatives as fungi-inhibitors belonging to 16 amino acids conjugated 2- amnio-arylthiazole was subjected computationally to quant. structure-activity relationship (QSAR) anal. by optimization of chem. structures at min. energy using mol. mechanics (MM+) theory and the semi-empirical MO (AM1) method. Correlation of their exptl. inhibitory zones against three types of fungi, namely, Fusarium monoliforme, Aspergillus Flavus, and Aspergillus niger with obtained physiochem. parameters was carried out using multiple linear regression (MLR) anal. As a result, there excellent out of 12 models were correlated with numerous descriptors having correlation coefficient rang (0.967-0.843). discriminant models were selected depending on their correlation coefficients (R2), Fisher ratios (F), and standard errors (S). These QSAR results and the probable pharmacophore features identified in this study offer important structural insight into designing novel amino acids conjugated 2-amnio-arylthiazole. Other 15 thiazole derivatives was proposed and it found that they are in good inhibitory zones. The experimental process involved the reaction of 4-Phenylthiazol-2-amine(cas: 2010-06-2).SDS of cas: 2010-06-2
The Article related to amino acid arylthiazole antifungal quant structure activity relationship analysis, Pharmacology: Structure-Activity and other aspects.SDS of cas: 2010-06-2
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica