Breckenridge, Robin J. published the artcileInhibition of [3H]GABA binding to postsynaptic receptors in human cerebellar synaptic membranes by carboxyl and amino derivatives of GABA, Recommanded Product: 2-(2-Phenylthiazol-4-yl)acetic acid, the main research area is GABA receptor structure activity.
Fifty synthetic analogs of GABA [56-12-2] were tested for their ability to interact with GABA receptors, using [3H]GABA binding to human cerebellar membranes as an in vitro model. The most active compounds were aliphatic and heterocyclic aminosulfonic acids. Compounds with highly substituted n atoms were only weakly active unless a long alkyl chain, which can interact with the postsynaptic membrane, was present. A pyramidal N atom is favored for binding of GABA analogs to human cerebellar membranes.
Journal of Neurochemistry published new progress about GABA receptors Role: BIOL (Biological Study). 16441-28-4 belongs to class thiazole, name is 2-(2-Phenylthiazol-4-yl)acetic acid, and the molecular formula is C11H9NO2S, Recommanded Product: 2-(2-Phenylthiazol-4-yl)acetic acid.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica