Skaanderup, Philip R. published the artcileSynthesis of the Macrocyclic Core of (-)-Pladienolide B, Formula: C10H11NS2, the main research area is pladienolide B macrocyclic core stereoselective preparation.
An efficient synthesis of the macrocyclic core (I) of (-)-pladienolide B is disclosed. The concise route relies on a chiral auxiliary-mediated asym. aldol addition and an osmium-catalyzed asym. dihydroxylation to install the three oxygenated stereocenters of the macrocycle. This purely reagent-controlled and flexible strategy sets the stage for future analog syntheses and structure-activity relationship plotting of the appealing anticancer lead structure pladienolide B.
Organic Letters published new progress about Aldol addition, stereoselective. 171877-39-7 belongs to class thiazole, name is (S)-4-Benzylthiazolidine-2-thione, and the molecular formula is C10H11NS2, Formula: C10H11NS2.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica