Yu, Wensheng published the artcileDiscovery of MK-6169, a Potent Pan-Genotype Hepatitis C Virus NS5A Inhibitor with Optimized Activity against Common Resistance-Associated Substitutions, Recommanded Product: 2-Ethylthiazole-5-carbaldehyde, the main research area is imidazolylbenzooxazinoindole preparation MK6169 antiviral hepatitis C virus NS5A inhibitor.
We describe the discovery of MK-6169 (I), a potent and pan-genotype hepatitis C virus NS5A inhibitor with optimized activity against common resistance-associated substitutions. SAR studies around the combination of changes to both the valine and aminal carbon region of elbasvir led to the discovery of a series of compounds with substantially improved potency against common resistance-associated substitutions in the major genotypes, as well as good pharmacokinetics in both rat and dog. Through further optimization of key leads from this effort, MK-6169 (I) was discovered as a preclin. candidate for further development.
Journal of Medicinal Chemistry published new progress about Anti-hepatitis C virus agents. 933683-87-5 belongs to class thiazole, name is 2-Ethylthiazole-5-carbaldehyde, and the molecular formula is C6H7NOS, Recommanded Product: 2-Ethylthiazole-5-carbaldehyde.
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica