Axton, Christopher A. published the artcileNovel immunosuppressive butenamides, Category: thiazole, the publication is Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) (1992), 2203-13, database is CAplus.
2-[4-(1,1-Dimethylethyl)phenyl]thiophene was carboxylated using butyllithium and carbon dioxide to give 5-[4-(1,1-dimethylethyl)phenyl]thiophene-2-carboxylic acid. Conversion of the acid using di-Ph phosphazidate and triethylamine gave 5-[4-(1,1-dimethylethyl)phenyl]thiophene-2-carbonyl azide, which was rearranged in toluene at 110° with loss of nitrogen to give the isocyanate; this in turn was treated with sodium 1-cyanoprop-1-ene 2-oxide in THF to give 2-cyano-N-{5-[4-(1,1-dimethylethyl)phenyl]thiophen-2-yl}-3-hydroxybut-2-enamide (I). Analogous chem. has been utilized to synthesize both heteroarylphenylbutenamides, e.g., II and III and phenylbutenamides, e.g., IV ( R= Cl, Bu, Me2CH, Me3C, EtMe2C, PrMe2C), which display immunosuppressive activity towards proliferating Con A-stimulated T-lymphocytes.
Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about 92-36-4. 92-36-4 belongs to thiazole, auxiliary class Organic Pigment, name is 2-(4-Aminophenyl)-6-methylbenzothiazole, and the molecular formula is C14H12N2S, Category: thiazole.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica