Bhoi, Manoj N. published the artcileNovel benzothiazole containing 4H-pyrimido[2,1-b]benzothiazoles derivatives: One-pot, solvent-free microwave assisted synthesis and their biological evaluation, HPLC of Formula: 95-24-9, the publication is Arabian Journal of Chemistry (2019), 12(8), 3799-3813, database is CAplus.
A series of pyrimido[2,1-b]benzothiazoles I [R = H, 6-Me, 8-Br, etc.] was synthesized via microwave-assisted one-pot three-component reaction of 2-aminobenzothiazoles with pyridine-2-aldehyde and Et acetoacetate in the presence of PdCl2 as an expeditious catalyst under solvent-free conditions. The salient features of this approach were operational simplicity, convergence, short reaction time, high atom economy, easy workup, mild reaction conditions and environmentally benign conditions. All the newly synthesized pyrimido[2,1-b]benzothiazole derivatives were evaluated for their antibacterial, antitubercular and antioxidant activities. Among the tested compounds, pyrimido[2,1-b]benzothiazoles I [R = 6-Me, 8-Me, 6-Cl, 8-Cl, 8-NO2] were found to be more active against tested Gram +ve and Gram -ve bacterial strains. Pyrimido[2,1-b]benzothiazoles I [R = 8-Me, 8-NO2] showed very good % inhibition 72.9% and 70.32% resp. against Mycobacterium tuberculosis H37RV whereas remaining compounds displayed moderate to good antitubercular activity. All the pyrimido[2,1-b]benzothiazoles I showed moderate to good antioxidant activity.
Arabian Journal of Chemistry published new progress about 95-24-9. 95-24-9 belongs to thiazole, auxiliary class Organic Pigment, name is 6-Chlorobenzothiazol-2-ylamine, and the molecular formula is C7H5ClN2S, HPLC of Formula: 95-24-9.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica