Kumar, Nag S. published the artcileSynthesis of a tritium-labeled photo-affinity probe based on an atypical leukotriene biosynthesis inhibitor, Synthetic Route of 5053-24-7, the publication is Journal of Labelled Compounds and Radiopharmaceuticals (2011), 54(1), 43-50, database is CAplus.
A radiolabeled photo-affinity probe containing a diazirine group was designed and synthesized based on an atypical leukotriene (LT) biosynthesis inhibitor to determine whether this type of inhibitor (such as 5) interacts with a novel protein, critical for LT biosynthesis. One of the key transformations was to introduce a tritium label in the thiazole ring. This was eventually achieved by treating the iodinated compound with tritium, Pt/C (sulfided) and triethylamine in anhydrous aprotic solvent, to give the tritiated compound I with a specific activity of 303 GBq/mmol. The affinity probe will be used to identify the proteins and protein complexes with which this type of mols. interacts with in inflammatory cells. Copyright © 2010 John Wiley & Sons, Ltd.
Journal of Labelled Compounds and Radiopharmaceuticals published new progress about 5053-24-7. 5053-24-7 belongs to thiazole, auxiliary class Thiazole,sulfides, name is 2-(Methylthio)thiazole, and the molecular formula is C4H5NS2, Synthetic Route of 5053-24-7.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica