Vladimirov, V. G. published the artcileMethemoglobin-forming effect and its role in the mechanism of action of some radioprotectants of the 2,1,3-benzothiadiazole class, Related Products of thiazole, the publication is Radiobiologiya (1977), 17(6), 828-33, database is CAplus and MEDLINE.
Thirty min after i.p. administration to mice of radioprotective doses of benzo-2,1,3-thiadiazole(I) derivatives, the metHb level in blood did not exceed 5%. After administration of a toxic dose of 4-aminobenzo-2,1,3-thiadiazole [767-64-6] (150 mg/kg), metHb in mouse blood reached 14%. After oral administration of 4-aminobenzo-2,1,3-thiadiazole to dogs, metHb of blood reached almost 50%. By using substances preventing oxidation of Hb to metHb (isonicotinic acid hydrazide and 2-methoxy-9-phenazine sulfate), it was shown that metHb formed in mouse blood did not play a leading role in the manifestation of radioprotective and toxic properties of 4-aminobenzo-2,1,3-thiadiazole.
Radiobiologiya published new progress about 1753-29-3. 1753-29-3 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Amine, name is Benzo[d][1,2,3]thiadiazol-5-amine, and the molecular formula is C4H10Br2CoO2, Related Products of thiazole.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica