Hill, Matthew D. published the artcileDevelopment of spiroguanidine-derived α7 neuronal nicotinic receptor partial agonists, Category: thiazole, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(3), 578-581, database is CAplus and MEDLINE.
We describe the synthesis of quinuclidine-containing spiroguanidines and their utility as α7 neuronal nicotinic acetylcholine receptor (nAChR) partial agonists. The convergent synthetic route developed for this study allowed for rapid SAR investigation and provided access to a structurally diverse set of analogs. A potent and selective α7 nAChR partial agonist, N-(6-methyl-1,3-benzoxazol-2-yl)-3′,5′-dihydro-4-azaspiro[bicyclo[2.2.2]octane-2,4′-imidazole]-2′-amine (BMS-910731, I), was identified. This compound induced immediate early genes c-fos and Arc in a preclin. rodent model of α7 nAChR-derived cellular activation and plasticity. Importantly, the ability to incorporate selectivity for the α7 nACh receptor over the 5-HT3A receptor in this series suggested a significant difference in steric requirements between the two receptors.
Bioorganic & Medicinal Chemistry Letters published new progress about 31784-71-1. 31784-71-1 belongs to thiazole, auxiliary class Other Aromatic Heterocyclic,Chloride,Amine, name is 5-Chlorothiazolo[5,4-b]pyridin-2-amine, and the molecular formula is C6H4ClN3S, Category: thiazole.
Referemce:
https://pubchem.ncbi.nlm.nih.gov/compound/thiazole,
Thiazole | chemical compound | Britannica