Oral Cancer Immunotherapy through a Simvastatin-Loaded Colloidal Dispersion System for the Generation of Sustained Antitumor Immunity was written by Kim, Seong A.;Nam, Gi-hoon;Bae, Young Rang;Jha, Saurav Kumar;Kim, Seohyun;Choi, Yoonjeong;Lee, Yeji;Kwon, Minsu;Jeong, Cheolhyun;Byun, Youngro;Park, Jin Woo;Kim, In-San. And the article was included in Advanced Therapeutics (Weinheim, Germany) in 2021.Recommanded Product: 38215-36-0 The following contents are mentioned in the article:
Statins exhibit anticancer pleiotropic effects, such as the induction tumor-specific apoptosis and the promotion antitumor immunity. However, due to low bioavailability, high doses are required to trigger such antitumor effects. In this study, an oral delivery system to improve bioavailability of simvastatin (SIMVA) is prepared and its application in combination with an oral anticancer formulation is investigated. A colloidal dispersion (CD) of SIMVA is prepared using Nα-deoxycholyl-L-lysyl-methylester (DL) to enhance a solubility and permeation (SIMVA/DL-CD). Preparation of SIMVA/DL-CD markedly increases the solubility and in vitro artificial membrane permeability of SIMVA by 291- and 4.68-fold, resp., compared to SIMVA in 5% DMSO. The oral absorption of SIMVA/DL-CD (20 mg kg-1 SIMVA) is significantly enhanced and its oral bioavailability is tenfold higher compared to that of free SIMVA. An in vivo study in CT26 tumor-bearing mice receiving SIMVA/DL-CD reveals substantial tumor growth suppression through upregulated anticancer immunity. In particular, the combination of oral SIMVA/DL-CD and oxaliplatin powder formulation elicits considerable tumor-suppressive effects and CD8+ T cell immunity. Furthermore, this combination therapy sensitizes antiprogramed cell death protein-1 monoclonal antibody-resistant tumors to checkpoint blockade. The current findings highlight the therapeutic potential of oral SIMVA/DL-CD as an effective anticancer immunotherapy. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Recommanded Product: 38215-36-0).
3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). The pyridine-type nitrogen in the thiazole ring deactivates the ring for electrophilic substitution reactions, which is further reduced in acid due to protonation of the thiazole ring.Recommanded Product: 38215-36-0
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica