Supersaturable self-emulsifying drug delivery system: A strategy for improving the loading and oral bioavailability of quercetin was written by Sirvi, Arvind;Kuche, Kaushik;Chaudhari, Dasharath;Ghadi, Rohan;Date, Tushar;Katiyar, Sameer S.;Jain, Sanyog. And the article was included in Journal of Drug Delivery Science and Technology in 2022.COA of Formula: C20H18N2O2S The following contents are mentioned in the article:
Supersaturable Lipid based drug delivery systems have gained much attention as bio-enabling formulation approach for oral delivery of drugs with high dose. Hence, the present investigation involves the preparation of quercetin (QT) loaded supersaturable self-emulsifying drug delivery system (QT-sSEDDS). Capmul MCM EP, Tween 20 and ethanol were used as chief components of preconc. which were selected based on solubility studies. Precipitation inhibitors (PI) were screened based on apparent drug concentration profile with respect to time where, HPMC E5 at 2.5% weight/weight was found suitable for the desired purpose. The QT-sSEDDS were characterised for their size, stability, functional stability and precipitate characterization, which revealed promising results. Further, solubilisation potential of QT-sSEDDS was evaluated using pH-stat lipolysis method which revealed ∼1.25 fold higher %QT content in aqueous state in comparison to QT-sSEDDS without PI. The cell uptake studies on Caco-2 cells (qual. and quant.) revealed significantly higher uptake in case of sSEDDS (Coumarin-6 or QT loaded) over free groups. These in vitro results were corroborated by in vivo pharmacokinetic data where, QT-sSEDDS revealed ∼2.2 and 2-fold increase in Cmax (at 4 h) and AUC resp. in comparison to conventional QT-SEDDS. Hence, it can be suggested that sSEDDS can potentially be used in delivering poorly soluble drug, QT which shows dose dependent bioavailability. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0COA of Formula: C20H18N2O2S).
3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). Thiazole is a versatile building block for the construction and lead generation of new drug discoveries. Numerous diazole-based compounds are in clinical use as anticancer, antileukemic, antiinflammatory, antiviral, antifungal, antirheumatic, immunomodulator, and antiparasitic agents.COA of Formula: C20H18N2O2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica