Pharmacoengineered Lipid Core-Shell Nanoarchitectonics to Influence Human Alveolar Macrophages Uptake for Drug Targeting Against Tuberculosis was written by Thalla, Maharshi;Vijayakumar, Gangipangi;Selvaraju, Sudhagar;Banerjee, Subham. And the article was included in Journal of Inorganic and Organometallic Polymers and Materials in 2022.Electric Literature of C20H18N2O2S The following contents are mentioned in the article:
Macrophage uptake and modulation based on nanoparticle characteristics are key areas for improving the internalisation process and successfully delivering the drug to intracellular organelles where Mycobacterium tuberculosis resides and persists. The two methods for designing nanoarchitectonics are active and passive targeting. Owing to the limitations of therapeutic approaches, we aimed to build nanoarchitectonics with both passive and active targeting properties. Lipid core-shell nanoarchitectonics were prepared using the double emulsification method, and their size, zeta potential, surface morphol., thermal and crystalline behavior, and pyrazinamide (PZA) payload and release were determined In human alveolar macrophages, comparative uptake, intracellular and compartmental colocalisation, and effectiveness against Mycobacterium smegmatis-infected macrophages were examined Nanoarchitectures obtained with smooth and hydrophobic surfaces were monodisperse, had a neg. zeta potential, and were irregular in shape. Furthermore, macrophage uptake and intracellular and compartmental colocalisation were more evident in macrophage cell lines, and increased efficacy was observed in the bacterium-infected cell lines. These findings show that ligand-tethered and PZA-loaded nanoarchitectonics are promising strategies for tuberculosis (TB) treatment. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Electric Literature of C20H18N2O2S).
3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. Thiazoles in peptides or their ability to bind proteins, DNA and RNA has led to many synthetic studies and new applications. Thiazole sulfonation occurs only under forcing conditions: the action of oleum at 250 °C for 3 hours in the presence of mercury(II) sulfate leads to 65% formation of 5-thiazole sulfonic acid.Electric Literature of C20H18N2O2S
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica