Rapid visualizing and pathological grading of bladder tumor tissues by simple nanodiagnostics was written by Liu, Hongxing;Mei, Chaoming;Deng, Xuanru;Lin, Weiqiang;He, Lizhen;Chen, Tianfeng. And the article was included in Biomaterials in 2021.Related Products of 38215-36-0 The following contents are mentioned in the article:
Developing a tissue diagnosis technol. to avoid the complicated processes and the usage of expensive reagents while achieving rapid pathol. grading diagnosis to provide a better strategy for clin. treatment is an important strategy of tumor diagnose. Herein, we selected the integrin αvβ3 as target based on the anal. of clin. data, and then designed a stable and cancer-targeted selenium nanosystem (RGD@SeNPs) by using RGD polypeptide as the targeting modifier. In vitro experiments showed that RGD@SeNPs could specifically recognized tumor cells, especially in co-culture cells model. The RGD@SeNPs can be used for clin. samples staining without the use of primary and secondary antibody. Fluorescence difference of the tissue specimens staining with RGD@SeNPs could be used to distinguish normal tissues and tumor tissues or estimate different pathol. grades of cancer at tissue level. 132 clin. tumor specimens with three types of tumor and 76 non-tumor specimens were examined which verified that the nanoparticles could specific and sensitive distinguish tumor tissue from normal tissue with a specificity of 92% and sensitivity of 96%. These results demonstrate the potential of cancer-targeted RGD@SeNPs as translational nanodiagnostics for rapid visualizing and pathol. grading of bladder tumor tissues in clin. specimens. This study involved multiple reactions and reactants, such as 3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0Related Products of 38215-36-0).
3-(Benzo[d]thiazol-2-yl)-7-(diethylamino)-2H-chromen-2-one (cas: 38215-36-0) belongs to thiazole derivatives. The thiazole ring is notable as a component of the vitamin thiamine (B1). There are numerous natural products that possess a thiazole ring with broad pharmacological activities. Thiamine, also known as vitamin B1, possesses a thiazole ring linked with 2-methylpyrimidine-4-amine as hydrochloride salt.Related Products of 38215-36-0
Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica