Samarasinghe, Ranmal A. et al. published their research in Nature Neuroscience in 2021 | CAS: 63208-82-2

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Electric Literature of C16H19BrN2OS

Identification of neural oscillations and epileptiform changes in human brain organoids was written by Samarasinghe, Ranmal A.;Miranda, Osvaldo A.;Buth, Jessie E.;Mitchell, Simon;Ferando, Isabella;Watanabe, Momoko;Allison, Thomas F.;Kurdian, Arinnae;Fotion, Namie N.;Gandal, Michael J.;Golshani, Peyman;Plath, Kathrin;Lowry, William E.;Parent, Jack M.;Mody, Istvan;Novitch, Bennett G.. And the article was included in Nature Neuroscience in 2021.Electric Literature of C16H19BrN2OS The following contents are mentioned in the article:

Brain organoids represent a powerful tool for studying human neurol. diseases, particularly those that affect brain growth and structure. However, many diseases manifest with clear evidence of physiol. and network abnormality in the absence of anatomical changes, raising the question of whether organoids possess sufficient neural network complexity to model these conditions. Here, we explore the network-level functions of brain organoids using calcium sensor imaging and extracellular recording approaches that together reveal the existence of complex network dynamics reminiscent of intact brain preparations We demonstrate highly abnormal and epileptiform-like activity in organoids derived from induced pluripotent stem cells from individuals with Rett syndrome, accompanied by transcriptomic differences revealed by single-cell analyses. We also rescue key physiol. activities with an unconventional neuroregulatory drug, pifithrin-a. Together, these findings provide an essential foundation for the utilization of brain organoids to study intact and disordered human brain network formation and illustrate their utility in therapeutic discovery. This study involved multiple reactions and reactants, such as 2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2Electric Literature of C16H19BrN2OS).

2-(2-Imino-4,5,6,7-tetrahydrobenzothiazol-3-yl)-1-p-tolylethanone Hydrobromide (cas: 63208-82-2) belongs to thiazole derivatives. The thiazole ring has been identified as a central feature of numerous natural products, perhaps the most famous example of which is epothilone. Electrophilic attack at nitrogen depends on the presence of electron density at nitrogen as well as the position and nature of substituent linked to the thiazole ring.Electric Literature of C16H19BrN2OS

Referemce:
Thiazole | C3H3NS – PubChem,
Thiazole | chemical compound | Britannica